A NEW APPROACH FOR DETECTING ADVENTITIOUS VIRUSES SHOWS SF-RHABDOVIRUS-NEGATIVE SF-RVN CELLS ARE SUITABLE FOR SAFE BIOLOGICALS PRODUCTION

A new approach for detecting adventitious viruses shows Sf-rhabdovirus-negative Sf-RVN cells are suitable for safe biologicals production

Abstract Background Adventitious viral contamination in cell substrates used for biologicals production is a major safety concern.A powerful new popularfilm.blog approach that can be used to identify adventitious viruses is a combination of bioinformatics tools with massively parallel sequencing technology.Typically, this involves mapping or BLASTN

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Outcomes of limited stage primary bone diffuse large B-cell lymphoma in the rituximab era: a multicenter, retrospective study

Primary bone diffuse large B-cell lymphoma is a rare variant of popularfilm.blog extranodal non-Hodgkin lymphoma historically treated with induction chemotherapy followed by consolidative radiation therapy (RT).It remains unknown whether RT confers additional benefit following rituximab-based chemoimmunotherapy (CIT) induction in patients with limi

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Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes.

We describe the first comprehensive analysis of the midgut metabolome of Aedes aegypti, the primary mosquito vector for arboviruses such as dengue, Zika, chikungunya and yellow fever viruses.Transmission of these viruses depends on their ability to infect, replicate and disseminate from several tissues in the mosquito vector.The metabolic environme

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